Select a suitable placebo fluid to emulate 'real' drug-product rheology safely and at acceptable cost, which is not always easy. (Note that results must be confirmed with the actual drug product once choices are narrowed).
Design and procure suitable fixtures to locate syringe and operate plunger/plunger stopper in test equipment.
Conduct a risk analysis to identify potential risks and failure modes associated with the delivery of the placebo fluid with a syringe, as:
Placebo toxicity hazard (e.g., irritant properties)
Possible needle-stick injury in later handling trials.
Some initial testing is useful to establish ballpark values; thereafter, modest sample sizes (as small as 10) may be sufficient to allow meaningful analysis.