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Warning Signs of Primary Immunodeficiency (PI) Cheat Sheet by

Detect warning signs of Primary Immunodefiency
medical     pi     primary     healthcare     immunodeficiency


Primary Immuno­def­iciency (PI) causes children and adults to have infections that come back frequently or are unusually hard to cure. 1:500 persons are affected by one of the known

Primary immuno­def­iciency diseases (PI) are a group of more than 300 rare, chronic disorders in which part of the body’s immune system is missing or functions improp­erly. While not contag­ious, these diseases are caused by hereditary or genetic defects, and, although some disorders present at birth or in early childhood, the disorders can affect anyone, regardless of age or gender. Some affect a single part of the immune system; others may affect one or more components of the system

Primary Immuno­def­ici­encies. If you or someone you know is affected by two or more of the following Warning Signs, speak to a physician about the possible presence of an underlying Primary Immuno­def­ici­ency.

Is it just an Infection?

You should be suspicious if you have an infection that is:
Severe: requires hospit­ali­zation or intrav­enous antibi­otics
Persistent: won’t completely clear up or clears very slowly
Unusual caused by an uncommon organism
Recurrent: keeps coming back or if it
Runs in the Family: others in your family have had a similar suscep­tib­ility to infection
If any of these words describe your infection, the Immune Deficiency Foundation (IDF) recommends that you ask your physician to check for the possib­ility of a primary immuno­def­iciency disease. These diseases are caused by genetic defects and can affect anyone, regardless of age or gender. People with primary immuno­def­ici­encies are more suscep­tible to infections and health problems that lead to serious and debili­tating diseases. It is critical to get an early diagnosis and proper medical care.

PI Awareness


Two or more new ear infections within 1 year.
Two or more new sinus infections within 1 year, in the absence of allergy.
One pneumonia per year for more than 1 year.
Chronic diarrhea with weight loss.
Recurrent viral infections (colds, herpes, warts, condyl­oma).
Recurrent need for intrav­enous antibi­otics to clear infect­ions.
Recurrent, deep abscesses of the skin or internal organs.
Persistent thrush or fungal infection on skin or elsewhere.
Infection with normally harmless tuberc­ulo­sis­-like bacteria.
A family history of PI.

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