Cheatography
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Treast diabetes insipidus, which occurs when the body produces an inadequate amount of antidiuretic hormone.
This is a draft cheat sheet. It is a work in progress and is not finished yet.
Medication Names
Prototype Med |
desmopressin (DDAVP) |
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Stimate |
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Minirin |
Other Meds |
vasopressin (Pitressin) |
Vasopressin is short acting
Action: causes the reabsorption of water, as opposed to the excretion of water, and it decreases urine volume.
Therapeutic Use
Diabetes insipidus |
NOTE: For detailed information about the use of desmopressin to treat hemo- philia, see the Hematologic System module |
Adverse Drug Reactions
Fluid retention (leading to water intoxication), hyponatremia |
Vasoconstriction (vasopressin, not desmopressin) |
Seizures |
Nursing Interventions
Monitor for headache, confusion, or other signs of water intoxication. |
Monitor fluid intake and output. |
Monitor serum sodium levels. |
Restrict fluid intake when appropriate. |
Recommend diuretic therapy for moderate and severe fluid retention. |
Interactions
Carbamazepine (Tegretol) and chlorpropamide (Diabinese) increase antidiuretic action. |
Other vasopressors and lithium (Lithobid) decrease antidiuretic action. |
Loop diuretics |
Glucocorticoids |
SSRIs, NSAIDs, thiazide diuretics |
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Administration
Administer orally, intranasally, subcutaneously, sublingually, or IV. |
Spray the nasal form high into the nasal cavity but not into the throat. Blow nose before. |
Monitor blood pressure, intake and output, urine and plasma osmolality, and creatinine clearance |
With IV vasopressin, monitor the IV insertion site, as extravasation can lead to gangrene |
Expect lifelong therapy |
Patient Education
Report pounding headache, sleepiness, fluid retention, weight gain, and edema. |
Limit fluid intake during therapy. |
Record fluid intake and output daily |
Report chest pain or pressure |
Contraindications
Vasopressin |
Coronary artery disease |
Poor peripheral circulation |
Chronic nephritis |
Desmopressin |
Electrolyte imbalances (oral form) |
Renal failure |
Nephrogenic diabetes insipidus |
Precautions
Older adults |
Cardiovascular disease |
Hypertension |
History of hyponatremia |
Severe heart failure |
History of thromboembolic events |
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